COMPOSITION / CONTENTClaneksi 625 mg Tablets (Salut membrane)Each tablet contains Amoxicillin Trihydrate equivalent to 500 mg of Amoxicillin and clavulanate potassium equivalent to 125 mg of clavulanic acid.Claneksi SyrupAfter the addition of the water, each 5 ml syrup Claneksi contains Amoxicillin Trihydrate equivalent to 125 mg of Amoxicillin and clavulanate potassium equivalent to 31,25mg clavulanic acid.Claneksi Forte Syrup
PHARMACOLOGYClaneksi is a combination antibiotic containing amoxicillin and clavulanic acid.Amoxicillin is a penicillin derivative antibiotics that have a broad spectrum semisintetis. Amoxicillin is active against Gram-positive and Gram-negative, bakterisid works by inhibiting the synthesis of the bacterial cell wall so that the bacterial cell wall weakening, plasma cells out and then broke.While clavulanic acid is an inhibitor of various types of β-lactamase enzymes produced by certain bacteria. The workings of clavulanic acid are:Serves as a competitive inhibitor because clavulanic acid chemical structure very similar to penicillin, clavulanic acid can occupy the active part of the structure of the β-lactamase enzyme without a chemical reaction.Carbonyl group of the β-lactamase enzyme penicillinase clavulanic acid change into the native enzyme. The original form of the enzyme is not active against penicillin.
INDICATIONSClaneksi indication is for the treatment of bacterial infections caused by microorganisms that are sensitive to Co-amoxiclav such as:Upper respiratory tract infections such as tonsillitis, sinusitis, otitis media.Lower respiratory tract infections such as acute and chronic bronchitis, lobar pneumonia and bronchopneumonia.Gastrointestinal infections (gastroenteritis) such as salmonella enteritis.Endocarditis prophylaxis.Urinary tract infections such as gonorrhea, urethritis, cystitis, pyelonephritis.Skin and soft tissue infections such as abscesses, cellulitis, ulcers.Bone and joint infections such as osteomyelitis.Acute otitis mediaDental infectionsOther infections
CONTRAINDICATIONClaneksi not be given to:Patients who are hypersensitive to penicillin or clavulanic acid.Newborns whose mothers hypersensitivity to penicillin or its derivatives or clavulanic acid.Have a history of cholestatic jaundice (impaired liver function).DOSAGE AND RULES FOR USEAsk your doctor about the dosage and the rules of use Claneksi.A common dose given is: Adults and children & gt; 12 years: 250-500 mg, 3 times a day. Children: 20-40 mg / kbBB / day in 2 divided doses.Claneksi should be given concurrently with food to avoid adverse effects on the gastrointestinal tract.Treatment should not be more than 14 days without re-examination by a doctor.SIDE EFFECTSClaneksi side effects that may occur are:Gastrointestinal disorders such as diarrhea, nausea, vomiting, pseudomembranous colitis, and candidiasis.A slight increase in AST and / or ALT in patients with penicillin semisintetis.Hepatitis and cholestatic jaundice, can gain weight and lasted for several months, especially in adults or elderly, and more frequently in male patients. The symptoms can be seen during the treatment, but more frequently reported after 6 weeks of treatment was stopped. The incidence of hepatic usually reversible.Urticaria and erythematous rashes.Erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis and exfoliative dermatitis. Treatment should be discontinued jlka these side effects occur.Angioedema and anaphylactic reactions.Interstitial nephritis.Transient leukopenia, thrombocytopenia and hemolytic anemia.
CAUTIONClaneksi use caution in patients with severe hepatic impairment.In patients with moderate renal function impairment or severe, the dose should be adjusted.The use of high doses or long term can lead to superinfection (commonly cause Enterobacter, Pseudomonas, S. aureus, Candida) mainly in the gastrointestinal tract.Claneksi film-coated tablets are not recommended for pregnant and lactating women unless deemed necessary by the physician.Drug InteractionsCan reduce the efficacy of oral contraceptives.May increase bleeding time and prothrombine time in patients receiving anticoagulant treatment.
PACKAGINGClaneksi 625 mg tablets, boxes, 5 strips @ 6 caplets.Claneksi dry syrups, vials, 60 mlClaneksi dry syrups forte, bottles, 60 ml.SHAKE BEFORE USE
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